[Blood lymphocyte ultrastructure in chronic lymphoproliferative diseases]

The authors have found that in chronic B-cell lymphoid leukemia and splenic lymphocytoma the proportion of irregular nuclei diminishes, in some patients split nuclei emerged. The proportion of irregular nuclei in lymphocytoma is significantly higher than that in chronic leukemia. The above diseases are characterized by disordered position of mitochondria in relation to cell center and of this center against nuclear invaginations. Microvilli on the cell surface become less numerous. It is suggested that in chronic lymphoproliferative diseases cytoskeleton in tumor cells may undergo structural and functional alterations.