Related Experiment Video
Updated: Aug 10, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Conservative therapy for gastroesophageal reflux in infants with obstructive pulmonary disease
1Pediatric Pulmonology Clinic, Tripler Army Medical Center, HI 96859-5000, USA.
Insights
Gastroesophageal reflux (GER) in infants can be linked to recurrent obstructive pulmonary disease (ROPD). Conservative GER therapy significantly improved ROPD symptoms in three infants studied.
Area of Science:
- Pediatric Gastroenterology
- Neonatal Respiratory Medicine
- Infant Health
Background:
- Gastroesophageal reflux (GER) is a common infant issue.
- Establishing a direct link between GER and recurrent obstructive pulmonary disease (ROPD) in infants is challenging.
- ROPD presents a significant respiratory concern in early childhood.
Observation:
- This review focuses on three infant cases.
- All infants presented with both GER and severe ROPD.
- The study observed the effects of conservative GER management.
Findings:
- Conservative therapy for GER led to substantial improvement in ROPD symptoms.
- The infants showed a dramatic positive response to the intervention.
- This suggests a potential therapeutic connection between GER and ROPD.
Implications:
- Conservative GER management may be an effective strategy for infants with ROPD.
- Further research is warranted to confirm the causal link and optimize treatment.
- Early intervention in infants with GER-ROPD could improve respiratory outcomes.
Abstract:
Gastroesophageal reflux (GER) is a commonly recognized problem in infants. However, it is difficult to demonstrate a causal relationship between GER and recurrent obstructive pulmonary disease (ROPD) in infants. In this review, 3 infants with GER and severe ROPD experienced dramatic improvement with conservative GER therapy.
Related Concept Videos
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease
