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Movement disorders in multiple sclerosis

C Tranchant1, K P Bhatia, C D Marsden

  • 1University Department of Neurology, Institute of Neurology, London, UK.

Movement Disorders : Official Journal of the Movement Disorder Society
|July 1, 1995
PubMed
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Movement disorders like dystonia and myoclonus are infrequent in multiple sclerosis (MS). Demyelinating lesions can cause specific movement disorders, but others may be coincidental.

Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Movement disorders (MD), excluding tremor, are uncommon in multiple sclerosis (MS).
  • Understanding the relationship between MS lesions and specific MDs is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the association between demyelinating lesions in MS and various movement disorders.
  • To differentiate MDs caused by MS lesions from those occurring coincidentally.

Main Methods:

  • Case series analysis of 14 new patients with MS-associated movement disorders.
  • Literature review of 135 previously reported cases.
  • Correlation of specific movement disorder types with the location of demyelinating lesions.

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Main Results:

  • Nine patients presented with dystonia, three with parkinsonism, and two with myoclonus.
  • Paroxysmal dystonias, ballism/chorea, and palatal myoclonus were linked to demyelinating lesions.
  • Parkinsonism, other dystonias, and myoclonus types frequently appeared coincidental.

Conclusions:

  • Demyelinating lesions in MS can directly cause certain movement disorders, including paroxysmal dystonias and chorea.
  • Other movement disorders, such as parkinsonism, may not be directly caused by MS lesions.
  • Distinguishing lesion-related MDs from coincidental ones is important in MS patient care.