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Calcium signalling and cell proliferation

M J Berridge1

  • 1Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, Cambridge, UK.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 1, 1995
PubMed
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Calcium signaling regulates the cell cycle, activating genes for cell entry and DNA synthesis. This pathway is a target for cancer therapies and immunosuppressants.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell cycle progression is a tightly regulated process.
  • Calcium signaling is a ubiquitous system involved in cellular regulation.
  • Inositol trisphosphate (InsP3) mediates prolonged, oscillatory calcium signals crucial for cell cycle control.

Purpose of the Study:

  • To elucidate the role of calcium signaling in cell cycle regulation.
  • To understand how calcium signals influence cell cycle transitions.
  • To highlight the therapeutic potential of targeting calcium pathways in diseases like cancer.

Main Methods:

  • Investigated the role of calcium influx and release from internal stores.
  • Examined the activation of immediate early genes by calcium signals.

Related Experiment Videos

  • Studied the impact of calcium on DNA synthesis and mitosis.

    • Main Results:

    • Calcium signals, generated by InsP3, are essential for quiescent cells to re-enter the cell cycle.
    • Calcium promotes DNA synthesis at the G1/S transition.
    • Calcium signaling contributes to mitotic events, completing the cell cycle.

    Conclusions:

    • Calcium signaling is a critical regulator of cell proliferation.
    • The calcium signaling pathway represents a promising target for anticancer and immunosuppressant drug development.