Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Psychostimulants in post-stroke depression

P Masand1, G B Murray, P Pickett

  • 1Psychiatric Consult Service, Massachusetts General Hospital, Boston, USA.

The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebral arteriovenous fistula to pulmonary artery onyx embolization.

Journal of perinatology : official journal of the California Perinatal Association·2007
Same author

Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS.

Current psychiatry reports·2003
Same author

Medical illness, past depression, and present depression.

Current psychiatry reports·2001
Same author

Abuse of topical analgesic.

The American journal of psychiatry·2001
Same author

Anxiety and position-dependent neurologic findings due to autonomic dysreflexia.

Psychosomatics·2001
Same author

SSRI-induced sexual dysfunction treated with sildenafil.

Depression and anxiety·1999
Same journal

The Neuropsychiatric Phenotype of Klüver-Bucy Syndrome: A Systematic Review of Reported Cases.

The Journal of neuropsychiatry and clinical neurosciences·2026
Same journal

Diffusion Tensor Imaging Correlates of Financial Capacity Instrument-Short Form Completion Time in Mild Cognitive Impairment.

The Journal of neuropsychiatry and clinical neurosciences·2026
Same journal

A 3-Week Intensive Outpatient Program for Patients With Persistent Neuropsychiatric Symptoms After Remote TBI.

The Journal of neuropsychiatry and clinical neurosciences·2026
Same journal

Outcomes of Integrated Practice Unit Treatment for Mild Traumatic Brain Injury and Co-occurring Conditions Among Veterans.

The Journal of neuropsychiatry and clinical neurosciences·2026
Same journal

Case Study 12: A 57-Year-Old Man With Seizures, Paranoid Psychosis, and Catatonia.

The Journal of neuropsychiatry and clinical neurosciences·2026
Same journal

Rates of Comorbid Psychiatric Conditions Among Adults With Hydrocephalus at a Hydrocephalus Specialty Center.

The Journal of neuropsychiatry and clinical neurosciences·2026
See all related articles

Psychostimulants like dextroamphetamine and methylphenidate offer a safe and effective treatment for post-stroke depression. Most patients experienced rapid symptom improvement with minimal side effects.

Area of Science:

  • Neurology
  • Psychiatry
  • Pharmacology

Background:

  • Post-stroke depression is a common complication following a stroke.
  • Current treatments may have limitations or side effects.
  • Exploring alternative therapeutic options is crucial for patient recovery.

Purpose of the Study:

  • To evaluate the efficacy and safety of psychostimulants in treating post-stroke depression.
  • To compare the effectiveness of dextroamphetamine and methylphenidate.
  • To assess the speed of symptom improvement and adverse reactions.

Main Methods:

  • Retrospective chart review of 17 patients with post-stroke depression.
  • Treatment involved either dextroamphetamine or methylphenidate.
  • Data collected on symptom improvement, efficacy, and adverse events.

Related Experiment Videos

Main Results:

  • 82% of patients showed improvement with psychostimulant treatment.
  • 47% experienced marked or moderate improvement in depressive symptoms.
  • No significant differences in efficacy were observed between the two drugs or depression subtypes.
  • Rapid improvement (within 2 days) was common.
  • Adverse reactions were infrequent, and anorexia was not observed.

Conclusions:

  • Psychostimulants are a safe and rapidly effective treatment for inpatient post-stroke depression.
  • They represent a viable alternative to traditional antidepressants like tricyclic antidepressants.
  • Further research may support wider clinical adoption.