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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Updated: May 7, 2026

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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Optical biopsy and imaging using optical coherence tomography

J G Fujimoto1, M E Brezinski, G J Tearney

  • 1Department of Electrical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA.

Nature Medicine
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) offers high-resolution, cross-sectional imaging for biological tissues. This innovative optical biopsy technique enables non-excision diagnostic imaging of tissue morphology, impacting disease diagnosis and management.

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Ophthalmology

Background:

  • Optical coherence tomography (OCT) is an emerging imaging modality.
  • It provides high-resolution, micrometre-scale, cross-sectional imaging of biological tissues.
  • OCT has seen preliminary clinical adoption in ophthalmology.

Purpose of the Study:

  • To explore the potential of OCT as an 'optical biopsy' technique.
  • To assess the feasibility of OCT for non-excision diagnostic imaging of tissue morphology.
  • To identify optimal clinical applications and necessary engineering advancements for OCT.

Main Methods:

  • Utilizing high-resolution, cross-sectional imaging capabilities of OCT.
  • Developing 'optical biopsy' techniques for in vivo tissue analysis.
  • Investigating catheter- or endoscope-based OCT for minimally invasive imaging.

Main Results:

  • Preliminary studies indicate the feasibility of OCT for diagnostic imaging.
  • OCT enables non-excision evaluation of tissue morphology.
  • The technology shows potential for a wide range of clinical and research applications.

Conclusions:

  • OCT is a promising technology for 'optical biopsy', offering non-excision tissue morphology assessment.
  • Further research and engineering are needed for widespread clinical integration.
  • OCT has the potential to significantly impact the diagnosis and management of various diseases.