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Clinical neurophysiology and neurotransmitters
A Maertens de Noordhout1, W Wang, J Schoenen
1University Department of Neurology, CHR Citadelle, Liège, Belgium.
Cephalalgia : an International Journal of Headache
|January 1, 1995
Summary
Clinical neurophysiology offers non-invasive methods to assess neurotransmitter function across the nervous system. This review explores its application in understanding brain disease pathophysiology and headache mechanisms.
Area of Science:
- Neuroscience
- Clinical Neurophysiology
Background:
- Clinical neurophysiology provides non-invasive methods for evaluating neurotransmitter function.
- Understanding neurotransmission is crucial for deciphering the pathophysiology of neurological disorders.
Purpose of the Study:
- To review the functional evaluation of neurotransmission using clinical neurophysiology.
- To explore the pharmacological modulation of electrophysiological tests.
- To discuss the relationship between electrophysiological tests and neurotransmitter function in headache.
Main Methods:
- Functional evaluation of neurotransmission at the neuromuscular junction, spinal interneurons, and intracortical circuits.
- Assessment of pharmacological modulation of electrophysiological tests.
- Analysis of evoked/event-related potentials and exteroceptive suppression of temporalis muscle activity.
Main Results:
- Demonstrated examples of evaluating neurotransmission in various neural circuits.
- Showcased the impact of pharmacological interventions on electrophysiological measures.
- Highlighted potential links between specific electrophysiological tests and neurotransmitter function in headache patients.
Conclusions:
- Clinical neurophysiology is a valuable tool for assessing neurotransmitter function non-invasively.
- Electrophysiological findings may offer insights into the neurophysiological underpinnings of headache.
- Further research can elucidate the role of neurotransmitters in neurological conditions through these methods.