Transverse myelopathy complicating mixed connective tissue disease

Area of Science:

• Neurology
• Rheumatology
• Immunology

Background:

• Mixed connective tissue disease (MCTD) is an autoimmune disorder with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis.
• Neurological complications, while known in MCTD, are less common than in other connective tissue diseases.
• Transverse myelitis, an inflammation of the spinal cord, is a rare but serious neurological manifestation.

Observation:

• A 46-year-old female patient presented with symptoms indicative of transverse myelitis.
• The patient was diagnosed with co-existing mixed connective tissue disease (MCTD).
• Transverse myelopathy is infrequently associated with MCTD compared to systemic lupus erythematosus (SLE).

Findings:

• The patient's transverse myelitis responded favorably to treatment with corticosteroids and immunosuppressive agents.
• The case underscores the potential for spinal cord inflammation in the context of MCTD.
• The study briefly reviews the underlying mechanisms, diagnostic approaches, and therapeutic strategies for transverse myelitis in MCTD.

Implications:

• This case expands the understanding of neurological manifestations in mixed connective tissue disease.
• It suggests that prompt diagnosis and treatment with immunosuppressive therapy can be effective for transverse myelitis in MCTD patients.
• Further research into the specific mechanisms and optimal management of transverse myelitis in MCTD is warranted.