[Abnormal expression and clinical significance of mutation p53 gene on human bladder cancer]

In order to study the relationships between the mutant p53 gene and human bladder cancer, the authors used in situ hybridization to detect 30 of bladder cancer and 4 of normal bladder samples. The results showed that p53 gene positive rate of mRNA was 23.3% in cancer patient, and all negative in normal-bladder. The positive rate was significantly different in pathological grading and clinical stages of carcinoma (P < 0.05). It suggests that the mutant p53 gene participats in transformation of carcinoma and may be used as a tumor marker for determinating invasiveness and prognosis of bladder carcinoma.