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Updated: Jul 25, 2026
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Generation of Human CD40-activated B cells
Published on: October 16, 2009
Altered CD40 ligand induction in tolerant T lymphocytes
1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.
European Journal of Immunology
|October 1, 1995
Summary
Anergic T cells, crucial for immune tolerance, fail to activate B cells due to defective CD40 ligand (CD40L) expression. This impairment hinders the recruitment of B cell responses by tolerant T cells.
Area of Science:
- Immunology
- T cell biology
- B cell activation
Background:
- CD40 ligand (CD40L) on T lymphocytes interacts with CD40 on B cells.
- This interaction is vital for B cell activation, immunoglobulin secretion, and Ig class switching.
Purpose of the Study:
- To investigate anergy as a mechanism of murine CD4 T cell tolerance.
- To determine if anergic T cells can stimulate B cell proliferation and CD40L expression.
Main Methods:
- In vivo and in vitro studies of CD3-activated anergic murine CD4 T cells.
- Assessed B cell proliferation and CD40L expression induction.
Main Results:
- Anergic T cells are deficient in stimulating B cell proliferation.
- Anergic T cells exhibit defective induction of CD40L expression mediated by T cell receptor/CD3.
Conclusions:
- Anergy in CD4 T cells impairs their ability to induce B cell responses.
- Defective CD40L expression on anergic T cells is a key mechanism limiting B cell activation.
