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[Do aerosol propellants produce a bronchoconstrictor effect? (author's transl)]
Deutsche Medizinische Wochenschrift (1946)
|February 2, 1979
Summary
Inhaling aerosol propellant can increase respiratory resistance in asthma patients. This effect is caused by a cold stimulus and can be blocked by ipratropium bromide.
Area of Science:
- Respiratory physiology
- Pharmacology
Context:
- Dosage aerosols are commonly used for respiratory medication delivery.
- Propellants in aerosols can cause local cooling effects.
Purpose:
- To investigate the effect of aerosol propellant inhalation on respiratory resistance.
- To determine the mechanism behind propellant-induced bronchoconstriction.
Summary:
- Inhalation of aerosol propellant increased respiratory resistance in 25 asthma patients and 3 laryngectomized patients.
- This effect was blocked by ipratropium bromide, suggesting a reflex mechanism.
- The bronchoconstriction is likely triggered by the low-temperature stimulus from the propellant.
Impact:
- Highlights a potential adverse effect of aerosol propellants.
- Suggests the utility of anticholinergic agents in managing propellant-induced respiratory changes.
- Informs the development and use of respiratory drug delivery systems.