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Iontophoresis in drug delivery: basic principles and applications
1Department of Dermatology, University of California-San Francisco 94143-0989, USA.
Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1994
Summary
Iontophoresis uses electrical potential to enhance drug delivery across epithelial barriers, proving effective for both ionic and neutral compounds. This technique shows promise for delivering large molecules like proteins and peptides systemically.
Area of Science:
- Biomedical Engineering
- Pharmaceutics
- Drug Delivery Systems
Background:
- Epithelial barriers limit passive drug absorption.
- Iontophoresis offers a method to enhance transdermal compound delivery.
- Recombinant DNA technology enables production of protein and peptide therapeutics.
Purpose of the Study:
- To review the principles and applications of iontophoresis.
- To highlight iontophoresis's potential for systemic drug delivery.
- To discuss the use of iontophoresis for protein and peptide delivery.
Main Methods:
- Review of existing literature on iontophoresis.
- Discussion of electrical potential gradient mechanism.
- Exploration of electroosmosis for neutral compound permeation.
Main Results:
- Iontophoresis successfully enhances delivery of ionic and neutral compounds.
- The technique has shown success in treating hyperhidrosis.
- Iontophoresis is effective for delivering charged and large molecules like proteins and peptides.
Conclusions:
- Iontophoresis is a versatile drug delivery system with broad applications.
- The technique is particularly promising for systemic delivery of biologics.
- Further research and application in various medical fields are warranted.