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Related Experiment Videos

Posterior keratoconus. Case report with scanning electron microscopy

S A al-Hazzaa1, C S Specht, I W McLean

  • 1Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, D.C., USA.

Cornea
|May 1, 1995
PubMed
Summary

This study details scanning electron microscopy findings in posterior keratoconus, revealing a smooth posterior corneal surface. This contrasts with prior research, offering new insights into this rare corneal condition.

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Microscopy

Background:

  • Posterior keratoconus is a rare corneal condition characterized by posterior ectasia.
  • Previous understanding of its pathology is based on limited case reports and imaging.

Observation:

  • A unilateral case in an older adult presented with clinical signs of posterior keratoconus, including a corneal iron ring.
  • Scanning electron microscopy (SEM) was performed on the explanted cornea.

Findings:

  • SEM revealed a pericentral posterior concavity without discrete irregularities on the posterior corneal surface.
  • The endothelial layer was intact but showed moderate pleomorphism; no Descemet's membrane excrescences or endothelial tags were observed.

Implications:

Related Experiment Videos

  • This case's SEM findings differ from previous descriptions, challenging the proposed link between posterior keratoconus and central corneal mesenchymal dysgenesis.
  • This is the first SEM report on posterior keratoconus, providing novel ultrastructural data.