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Mucinous adenocarcinoma in defunctionalized bladders
B Djavan1, S E Litwiller, S Milchgrub
1Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235-9110, USA.
Urology
|July 1, 1995
Summary
Primary adenocarcinoma of the bladder is rare. This study reports the first cases of adenocarcinoma developing in defunctionalized bladders, years after urinary diversion for prune belly syndrome and neurogenic bladder.
Area of Science:
- Urology
- Oncology
Background:
- Primary adenocarcinoma of the bladder is a rare malignancy, representing less than 2% of all bladder cancers.
- Carcinomas in defunctionalized bladders are typically squamous cell, signet ring cell, or transitional cell types.
- These tumors are usually associated with chronic inflammation and detected within 5 years post-urinary diversion.
Observation:
- This report details two unique cases of adenocarcinoma.
- The first case occurred 30 years after ileal loop diversion for prune belly syndrome.
- The second case developed 8 years after diversion for neurogenic bladder.
Findings:
- This is the first documented instance of adenocarcinoma arising in a defunctionalized bladder.
- The latency period for adenocarcinoma in these cases (8 and 30 years) is significantly longer than previously reported for other carcinoma types.
- Unlike prior reports, chronic inflammation was not a noted factor in these adenocarcinoma cases.
Implications:
- These findings expand the known spectrum of malignancies that can arise in defunctionalized bladders.
- The development of adenocarcinoma in defunctionalized bladders, even without chronic inflammation, suggests alternative oncogenic pathways.
- Further research is warranted to understand the specific mechanisms and risk factors for adenocarcinoma in this context.