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Related Experiment Videos

Bleeding time at altitude

H A Doughty1, C Beardmore

  • 1Department of Haematology, St Bartholomew's Hospital, London, UK.

Journal of the Royal Society of Medicine
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Bleeding time increases significantly during high-altitude ascent in unacclimatized individuals, indicating initial prothrombotic changes. These alterations revert as acclimatization progresses, suggesting complex compensatory mechanisms in coagulation factors.

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Area of Science:

  • Physiology
  • Altitude Medicine
  • Hematology

Background:

  • High-altitude ascent triggers significant physiological stress.
  • Coagulation disorders are recognized in unacclimatized individuals at altitude.
  • Understanding hematological changes is crucial for managing altitude-related risks.

Purpose of the Study:

  • To document the sequential hematological changes during high-altitude ascent.
  • To investigate the temporal dynamics of bleeding time in climbers.
  • To explore the relationship between altitude exposure and coagulation parameters.

Main Methods:

  • Weekly estimation of bleeding time in six climbers over a six-week period.
  • Monitoring climbers during ascent to 5700 meters.

Related Experiment Videos

  • Analysis of bleeding time trends in relation to altitude exposure and duration.

    • Main Results:

    • Median bleeding time increased by 50% between weeks 1 and 4.
    • Bleeding time plateaued during ascent to 5700 m.
    • Bleeding time reverted to baseline levels by week 6, despite continued altitude exposure.

    Conclusions:

    • Initial ascent to high altitude may induce a prothrombotic phase.
    • Compensatory changes in coagulation factors and increased capillary fragility may explain observed bleeding time alterations.
    • The temporal sequence of hematological changes during acclimatization is critical for thrombosis risk assessment.