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Interspecific complementation between mouse and Chinese hamster cell mutants hypersensitive to ionizing radiation

K Sato1, D J Chen, K Eguchi-Kasai

  • 1Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba, Japan.

Journal of Radiation Research
|March 1, 1995
PubMed

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...