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Related Experiment Videos

Changes in maternal plasma macrophage-colony stimulating factor levels during normal pregnancy

D P Tsakonas1, K H Nicolaides, C P Tsakona

  • 1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London, UK.

Clinical and Laboratory Haematology
|March 1, 1995
PubMed
Summary

Pregnancy increases macrophage-colony stimulating factor (M-CSF) and circulating monocytes after the first and second trimesters, respectively. M-CSF and monocyte levels rise independently during gestation.

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Area of Science:

  • Immunology
  • Reproductive Biology
  • Hematology

Background:

  • Macrophage-colony stimulating factor (M-CSF) plays a crucial role in monocyte development and function.
  • Changes in immune cell populations and cytokine levels are expected during pregnancy.

Purpose of the Study:

  • To investigate the longitudinal changes in M-CSF levels and circulating monocyte counts during normal singleton pregnancies.
  • To explore the relationship between M-CSF and monocyte parameters throughout gestation.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) for M-CSF quantification.
  • Automated blood analysis for absolute monocyte counts and percentages.
  • Study included 80 pregnant women (12-40 weeks) and 10 non-pregnant controls.

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Main Results:

  • M-CSF levels were significantly elevated in pregnancy after 28 weeks compared to controls.
  • Absolute monocyte number and percentage increased significantly with gestational age after 16 weeks.
  • No significant correlation was found between M-CSF concentrations and monocyte counts/percentages.

Conclusions:

  • Pregnancy is associated with a significant up-regulation of both M-CSF and circulating monocytes.
  • These changes suggest an important role for M-CSF and monocytes in supporting the pregnant state.
  • Monocyte and M-CSF increases appear to be regulated independently during gestation.