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Related Experiment Videos

Flare phenomenon in osteosarcoma after complete remission

K Herrlin1, H Willén, T Wiebe

  • 1Department of Diagnostic Radiology, University Hospital, Lund, Sweden.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|August 1, 1995
PubMed
Summary

The flare phenomenon can cause false positives in bone scans for osteosarcoma metastases. Radionuclide imaging may miss viable tumor cells in bone metastases.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Osteosarcoma is a primary malignant bone tumor.
  • Cytostatic therapy is used to treat osteosarcoma.
  • Bone scans are used to detect bone metastases.

Observation:

  • A patient with osteosarcoma experienced increased radiotracer accumulation in a bone scan.
  • This finding was confirmed by CT and MRI.
  • Biopsy revealed necrotic metastasis with no viable tumor cells.

Findings:

  • The study confirms the flare phenomenon in skeletal metastases of primary malignant bone tumors.
  • Radionuclide imaging may fail to detect intramedullary foci of viable metastases.

Implications:

  • The flare phenomenon can lead to misinterpretation of bone scans.
  • Alternative imaging modalities or biopsy may be necessary to confirm metastases.
  • This highlights the limitations of radionuclide imaging in specific cases of bone tumors.

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