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Absolute phasic blood flow measurement in the brain using digital subtraction angiography
A Ersahin1, S Y Molloi, J W Hicks
1Department of Radiological Sciences, University of California, Irvine 92717.
Investigative Radiology
|April 1, 1995
Summary
This study introduces a novel angiographic method for quantifying blood flow. The first-pass distribution analysis accurately measures phasic volumetric blood flow in phantoms and animal models.
Area of Science:
- Medical Imaging
- Cardiovascular Physiology
- Angiography
Background:
- Accurate quantification of phasic volumetric blood flow is crucial for understanding cardiovascular health.
- Traditional methods may have limitations in precision and real-time assessment.
Purpose of the Study:
- To develop and validate an angiographic method for quantifying phasic volumetric blood flow.
- To assess the efficacy of first-pass distribution analysis in conjunction with digital subtraction angiography.
Main Methods:
- Utilized digital subtraction angiography and a first-pass distribution algorithm.
- Employed videodensitometry to analyze contrast material conservation in arterial beds.
- Generated contrast pass curves from sequential images to determine instantaneous flow rates.
Main Results:
- Measurements in an angiographic phantom and rabbit carotid arteries showed strong correlation with ultrasound flow probes.
- The method demonstrated high accuracy, with correlation coefficients (r) of 0.96 and 0.98.
- Validation equations: M = 0.87 K + 2.50 mL/min and M = 0.92 K - 1.00 mL/min.
Conclusions:
- The first-pass distribution method combined with digital subtraction angiography shows significant potential for in vivo phasic arterial blood flow measurement.
- This technique offers a promising tool for quantitative cardiovascular assessment.