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The evolution of invasion by enteric bacteria

H Ochman1, E A Groisman

  • 1Department of Biology, University of Rochester, NY 14627, USA.

Canadian Journal of Microbiology
|July 1, 1995
PubMed
Summary

Many enteric pathogens use similar secretion systems for virulence, despite distinct diseases. These systems, though conserved in structure, likely evolved independently in different pathogens.

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Pathogenicity islands of Shigella.

Current topics in microbiology and immunology·2002

Area of Science:

  • Microbiology
  • Pathogen Biology
  • Molecular Biology

Background:

  • Enteric pathogens like Salmonella and Shigella employ specialized secretion machinery for virulence.
  • Similar protein export systems are observed in diverse animal and plant pathogens.

Purpose of the Study:

  • To investigate the conservation and evolutionary origins of virulence protein secretion pathways in pathogens.

Main Methods:

  • Comparative analysis of gene complexes encoding secretory pathways.
  • Phylogenetic analysis of sequence distribution.
  • Genomic location assessment of relevant gene clusters.

Main Results:

  • A conserved, similar machinery for virulence protein secretion exists across various enteric pathogens.
  • Gene complexes specifying these pathways show broad conservation in structure and organization.
  • Phylogenetic distribution and genomic locations suggest independent evolutionary origins for these pathways in divergent pathogens.

Conclusions:

  • The similar secretion machinery in pathogens is a case of convergent evolution.
  • Understanding these pathways is crucial for developing broad-spectrum anti-pathogen strategies.

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