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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Preclinical and clinical experience with cisplatin resistance
1Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA.
Abstract:
Despite the general lack of clinical evidence supporting the preclinical data, there have been many attempts to overcome cisplatin resistance in clinical situations. These efforts have focused on both the proposed mechanisms of resistance as well as novel approaches to renew efficacy. In this article, the authors summarize the available clinical studies that have intentionally or serendipitously uncovered modulators of cisplatin sensitivity.
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