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Dual receptor T-cells. Implications for alloreactivity and autoimmunity

E Padovan1, G Casorati, P Dellabona

  • 1Basel Institute for Immunology, Switzerland.

Annals of the New York Academy of Sciences
|July 7, 1995
PubMed

Using monoclonal antibodies to human V alpha, we have estimated that up to one-third of mature T-cells express two V alpha chains as part of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor. We discuss the possibility that dual receptor T-cells may be involved in alloreactivity and autoimmunity.

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