Related Experiment Videos
An effect of somatostatin on neurotensin secretion
T Sakamoto1, M Miyata, T Emoto
1First Department of Surgery, Osaka University Medical School, Japan.
Regulatory Peptides
|April 14, 1995
Abstract:
A somatostatin analog (SMS201-995) was administered subcutaneously to six totally pancreatectomized (TP) patients at five dose levels from 0 microgram/kg (control) to 2.5 micrograms/kg before ingestion of a liquid test meal, and plasma levels of neurotensin (NT) were measured. There were no significant differences in basal levels of NT between the doses of somatostatin. The NT levels were significantly elevated after ingestion of the test meal in the normal controls (n = 14). In the TP patients postprandial hypersecretion of NT was observed. The hypersecretion of NT in the patients was suppressed by SMS201-995 dose-dependently.