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[Monocyte recruitment in blood vessel wall]
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|April 1, 1995
Summary
Monocyte recruitment, the process of monocytes adhering to and migrating across endothelial cells, is crucial in disease. This review details its mechanisms, regulation by cytokines, and overall effects.
Area of Science:
- Cellular biology
- Immunology
- Vascular biology
Context:
- Monocyte recruitment is a key process in inflammatory and pathophysiological conditions.
- It involves the interaction between monocytes and vascular endothelial cells (EC).
Purpose:
- To discuss the process, characteristics, mechanisms, regulation, and effects of monocyte recruitment.
- To provide a comprehensive overview of this critical cellular event.
Summary:
- Monocyte recruitment involves monocyte adhesion to EC, followed by stretching and migration.
- Adhesive molecules and receptors are vital for this process.
- Cytokines and chemoattractants regulate monocyte recruitment.
Impact:
- Understanding monocyte recruitment is essential for developing therapeutic strategies targeting inflammatory diseases.
- This review highlights the complex molecular and cellular interactions governing monocyte migration.