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[Heredity and colorectal cancer]

S Civitelli1, B Civitelli, M C Pacchiarotti

  • 1Istituto di Clinica Chirurgica, Università degli Studi, Siena.

Minerva Chirurgica
|March 1, 1995
PubMed
Summary

Colorectal cancer survival has not improved despite advances, emphasizing prevention and early detection. Family history is crucial for identifying high-risk individuals for targeted colorectal cancer screening.

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Familial colorectal cancer: a concept revisited.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2008

Area of Science:

  • Oncology
  • Genetics
  • Public Health

Context:

  • Colorectal cancer (CRC) is a leading cause of cancer death in Western countries.
  • Despite treatment advances, survival rates remain largely unchanged.
  • Prevention and early detection are critical for improving outcomes.

Purpose:

  • To highlight the importance of inherited susceptibility and family history in colorectal cancer risk.
  • To discuss the limitations of current genetic screening methods for CRC.
  • To advocate for family history-based surveillance strategies.

Summary:

  • Familial clustering suggests genetic predisposition to colorectal cancer (CRC).
  • Hereditary CRC includes Familial Adenomatous Polyposis (FAP) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC).
  • Even sporadic CRC cases show increased risk in first-degree relatives, underscoring the role of family history.

Impact:

  • Family history analysis enables targeted surveillance for high-risk individuals.
  • This approach facilitates cost-effective management strategies for colorectal cancer.
  • Future screening ideally involves simple blood tests, but family history remains essential currently.

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