[The immunomorphological characteristics of experimental bacterial sepsis]

The experimental model of bacterial sepsis, based on the intraperitoneal inoculation of Staphylococcus aureus with the simultaneous suppression of sensitivity by the injection of prednisolone, has been developed in 40 guinea pigs. Sepsis is characterized by the generalization of the infection in the body and by the formation of disseminated purulent foci simultaneously with inflammatory and dystrophic changes in different organs. The development of experimental sepsis leads to an increase in the content of B lymphocytes and to the activation of humoral immunity simultaneously with the suppression of cell-mediated immunity.