[The safety, reactogenicity and antigenic activity of a Pseudomonas aeruginosa anatoxin studied in volunteers]

The safety, reactogenicity and immunogenic activity of P. aeruginosa toxoid were studied in 46 volunteer donors. Systemic reactions to the injection of the preparation were absent in all vaccinees, in 2 subjects (4.3%) insignificant reactions at the site of injection in the form of hyperemia, sized 13-14 mm and disappearing within 48 hours, were registered. The preparation was found stimulate humoral immunity, which was manifested by an increase in the number of B-rosette-forming lymphocytes and the level of antitoxic IgG in the blood of the vaccinees. Besides, immune sera obtained from the blood of the volunteers were found to possess protective properties.