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[Dynamic function tests for detection of physiologic and pathophysiologic reactions in cutaneous microcirculation]

H P Albrecht1, D Hiller, M Mück-Weymann

  • 1Dermatologische Klinik und Poliklinik, Friedrich-Alexander Universität, Erlangen-Nürnberg.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|July 1, 1995
PubMed
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Functional tests using arterial occlusion and heating effectively assess cutaneous microcirculation. These methods evaluate vascular reactivity and perfusion reserves, aiding in understanding conditions like systemic sclerosis.

Area of Science:

  • Physiology
  • Biomedical Engineering
  • Dermatology

Context:

  • Cutaneous microcirculation is crucial for physiological and pathophysiological assessments.
  • Non-invasive methods like laser-Doppler fluxmetry and oxygen tension measurements offer valuable insights.
  • Simulating local stresses aids in understanding the skin's response to various stimuli.

Purpose:

  • To evaluate physiological and pathophysiological patterns in cutaneous microcirculation using functional tests.
  • To determine post-stimulatory parameters reflecting vascular reactivity to hypoxia and ischemia.
  • To derive dynamic performance parameters indicating perfusion reserves and ischemic tolerance.

Summary:

  • Functional tests involving arterial occlusion and local heating effectively simulate local demands on cutaneous perfusion.

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  • Analysis of initial values and time-courses during these tests yields post-stimulatory parameters.
  • These parameters provide insights into vascular reactivity, perfusion reserves, and ischemic tolerance, exemplified by systemic sclerosis.

    • Impact:

    • Establishes functional tests as a valuable tool for assessing cutaneous microcirculation.
    • Enables quantitative evaluation of vascular reactivity and microcirculatory capacity under stress.
    • Provides a framework for understanding pathophysiological changes in skin conditions.