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Development and evaluation of a buccoadhesive propranolol tablet formulation

N Celebi1, O Kişlal

  • 1Department of Pharmaceutical Technology, Gazi Univeristy, Ankara, Turkey.

Die Pharmazie
|July 1, 1995
PubMed
Summary

This study developed propranolol buccoadhesive tablets using poly(acrylic)acid (PAA), hydroxypropylmethylcellulose (HPMC), and hydroxypropylcellulose (HPC). Formulations with higher PAA content exhibited superior adhesive strength and non-Fickian release kinetics.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Buccoadhesive drug delivery systems offer localized or systemic drug delivery with improved patient compliance.
  • Propranolol, a beta-blocker, is a candidate for buccoadhesive formulations due to its potential for oral mucosal absorption.

Purpose of the Study:

  • To formulate and characterize propranolol buccoadhesive tablets using various polymers.
  • To investigate the drug release mechanisms and adhesive properties of the developed tablets.

Main Methods:

  • Direct compression of propranolol with poly(acrylic)acid (PAA), hydroxypropylmethylcellulose (HPMC), and hydroxypropylcellulose (HPC) in varying ratios.
  • Drug release studies fitted to the Mt/M infinity = ktn equation.
  • Adhesion testing using a tensile tester apparatus on bovine buccal mucosa.

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Main Results:

  • Drug release followed a non-Fickian mechanism, best described by zero-order kinetics and slab erosion.
  • Formulations containing a high concentration of PAA demonstrated the strongest adhesive forces.
  • The combination of PAA, HPMC, and HPC enabled direct compression into buccoadhesive tablets.

Conclusions:

  • Poly(acrylic)acid is a key component for enhancing the mucoadhesive properties of propranolol tablets.
  • The developed buccoadhesive tablets exhibit promising characteristics for controlled drug release and effective adhesion.
  • Slab erosion and zero-order kinetics are the predominant release mechanisms for these propranolol formulations.