Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inner ear-specific autoantibodies

S Yamanobe1, J P Harris

  • 1Department of Surgery, University of California Medical Center, San Diego.

The Laryngoscope
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

School-based surveillance of acute infectious disease in children: a systematic review.

BMC infectious diseases·2021
Same author

Editorial.

Audiology & neuro-otology·2021
Same author

Understanding norovirus reporting patterns in England: a mixed model approach.

BMC public health·2021
Same author

Risk factors associated with outbreaks of seasonal infectious disease in school settings, England, UK.

Epidemiology and infection·2020
Same author

Symptom profiling for infectious intestinal disease (IID): a secondary data analysis of the IID2 study.

Epidemiology and infection·2019
Same author

The use of capture-recapture methods to provide better estimates of the burden of norovirus outbreaks from seafood in England, 2004-2011.

Epidemiology and infection·2018
Same journal

Discrimination of Pairs of Chemosensory Stimuli in Relation to Respiration.

The Laryngoscope·2026
Same journal

What Safety Precautions Are Recommended When Lasering in the Airway?

The Laryngoscope·2026
Same journal

Success of Anterior Ethmoidal Artery Flaps for Nasal Septal Perforation Repair: A Systematic Review.

The Laryngoscope·2026
Same journal

Laryngeal IgG4-Related Disease: A Systematic Review of Clinical Features and Management.

The Laryngoscope·2026
Same journal

Elevated BMI Is Not Associated With Adverse Outcomes in Open Airway Reconstruction.

The Laryngoscope·2026
Same journal

What is the Most Effective Treatment Approach for Vocal Fold Granuloma?

The Laryngoscope·2026
See all related articles

Researchers identified inner ear (IE)-specific autoantibodies in patients with idiopathic sensorineural hearing loss (SNHL). These autoantibodies may play a role in the cause and treatment of progressive SNHL.

Area of Science:

  • Immunology
  • Otolaryngology
  • Neuroscience

Background:

  • Idiopathic sensorineural hearing loss (SNHL) is a significant cause of hearing impairment.
  • The etiology of SNHL is often unknown, highlighting the need for research into potential autoimmune mechanisms.
  • Autoimmune inner ear disease is a recognized, though less common, cause of hearing loss.

Purpose of the Study:

  • To investigate the presence of inner ear (IE)-specific autoantibodies in the sera of patients with idiopathic SNHL.
  • To determine the specificity of these autoantibodies against IE antigens.
  • To explore the potential role of these autoantibodies in the pathogenesis of SNHL.

Main Methods:

  • Sera from patients with idiopathic SNHL were analyzed using qualitative immunoblotting (Western blotting).

Related Experiment Videos

  • Water-soluble and sodium dodecyl sulfate-soluble extracts from bovine IE tissues and other organs were used as antigens.
  • Autoantibody reactivity against specific molecular weight determinants (kd) was assessed.

    • Main Results:

    • Autoantibodies reacting with common antigenic determinants (68, 62, 55, 50, 47 kd) were found in 46 patients.
    • IE-specific autoantibodies reacting with unique determinants (220, 60, 58, 33-35, 32 kd) were identified in 13 patients.
    • The presence of these IE-specific autoantibodies was noted in patients with progressive SNHL.

    Conclusions:

    • The study identified IE-specific autoantibodies in a subset of patients with idiopathic SNHL.
    • These autoantibodies may have significant implications for understanding the etiology of progressive SNHL.
    • Further research is needed to purify these IE-specific antigens and evaluate their clinical utility for diagnosis and treatment.