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Sudden onset of adverse effects due to low-dosage bleomycin indicates an idiosyncratic reaction
T Haerslev1, C Avnstorp, M Joergensen
1Department of Pathology, Gentofte University Hospital, Hellerup, Denmark.
Cutis
|July 1, 1993
Abstract:
We report a case of possible idiosyncratic reaction in a fifty-two-year-old man with centroblastic malignant lymphoma. Immediately after administration of 20 mg bleomycin intravenously for the first time, the patient developed stomatitis. When readministered a few weeks later the patient developed mucocutaneous manifestations such as stomatitis, symmetrical linear maculopapular exanthema on the neck, trunk, and both arms, and indurated nodules on the palms.