Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reconstructing cortical connections in a dish

J Bolz1, M Götz, M Hübener

  • 1Friedrich-Miescher Labor der Max-Planck Gesellschaft, Tübingen, FRG.

Trends in Neurosciences
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phylogeny and taxonomy of <i>Acer</i> powdery mildews, including genera <i>Sawadaea</i> and <i>Takamatsuella</i> (<i>Erysiphaceae, Ascomycota</i>).

Studies in mycology·2026
Same author

Phylogeny and taxonomy of <i>Cercospora malkoffii</i> (<i>Mycosphaerellaceae</i>).

Fungal systematics and evolution·2025
Same author

EnGraft: a multicentre, open-label, randomised, two-arm, superiority study protocol to assess bioavailability and practicability of Envarsus® versus Advagraf™ in liver transplant recipients.

Trials·2023
Same author

On the adsorption and reactivity of element 114, flerovium.

Frontiers in chemistry·2022
Same author

Zeitschrift fur Gastroenterologie·2022
Same author

Zeitschrift fur Gastroenterologie·2022
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

Cortical development involves specific axon guidance. Studies show cultured neurons mirror in vivo connections, revealing guidance factors for navigating axons and target recognition.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • During cortical development, projection neurons and afferent fibers form precise connections.
  • Layer- and cell-specific connections observed in vitro resemble in vivo patterns.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying specific axonal connections in the developing cortex.
  • To identify guidance factors mediating target specificity in neuronal development.

Main Methods:

  • Utilizing in vitro culture systems to study cortical neuron development.
  • Comparing in vitro established connections with in vivo observations.

Main Results:

  • Demonstrated similarity between cultured and in vivo cortical connections.

Related Experiment Videos

  • Provided evidence for diffusible and membrane-bound guidance factors.
  • Indicated the involvement of distinct molecules in axon navigation, target innervation, and recognition.

    • Conclusions:

    • Guidance factors play a crucial role in establishing specific neuronal connections during cortical development.
    • Multiple molecular mechanisms are employed for accurate axon targeting and recognition.