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Related Experiment Videos

Vitronectin and its receptors

B Felding-Habermann1, D A Cheresh

  • 1Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037.

Current Opinion in Cell Biology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Vitronectin, an extracellular matrix protein, binds to specific cell receptors, influencing cell behavior. This interaction impacts critical processes like tumor metastasis and wound healing.

Area of Science:

  • Cell biology
  • Extracellular matrix research
  • Integrin signaling

Background:

  • Vitronectin is a key extracellular matrix protein.
  • It mediates cell adhesion through specific receptors.
  • Vitronectin's role extends to various physiological and pathological processes.

Purpose of the Study:

  • To outline the molecular interactions of vitronectin with its receptors.
  • To highlight the functional consequences of vitronectin-cell interactions.
  • To underscore the significance of vitronectin in cellular processes.

Main Methods:

  • Literature review on vitronectin and integrin interactions.
  • Analysis of cell adhesion assays and signaling pathways.
  • Examination of vitronectin's role in disease models.

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Main Results:

  • Vitronectin binds to integrins alpha v beta 1, alpha v beta 3, alpha v beta 5, and alpha IIb beta 3.
  • Cellular responses include adhesion, spreading, migration, growth, and differentiation.
  • These effects are implicated in tumor metastasis, wound healing, bone resorption, and viral infection.

Conclusions:

  • Vitronectin is a crucial regulator of cell behavior via integrin receptors.
  • Understanding these interactions is vital for therapeutic strategies.
  • Vitronectin signaling pathways are central to multiple biological functions.