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Surrogate tissues for detecting brain microemboli after cardiopulmonary bypass
W R Brown1, D M Moody, S A Mills
1Department of Radiology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1088.
Perfusion
|January 1, 1994
Summary
Microemboli lodge in the brain during cardiopulmonary bypass (CPB). However, skin and muscle tissues showed significantly fewer microemboli compared to brain tissue in patients undergoing CPB.
Area of Science:
- Cardiovascular Science
- Neurology
- Pathology
Background:
- Cardiopulmonary bypass (CPB) is associated with the risk of microemboli lodging in organs.
- Understanding microemboli distribution is crucial for mitigating CPB-related complications.
Purpose of the Study:
- To quantify microemboli in different tissues after cardiopulmonary bypass.
- To compare microemboli load in brain, skin, and muscle tissues.
Main Methods:
- Microemboli were counted in autopsy tissue samples (skin, muscle, brain) from patients who underwent CPB.
- Skin and muscle biopsies were analyzed from patients before and after CPB.
Main Results:
- The brain accumulated a significant number of microemboli post-CPB.
- Skin and muscle tissues exhibited a notably lower microemboli count compared to the brain.
Conclusions:
- Microemboli distribution after CPB is organ-specific, with the brain being a primary site.
- Skin and muscle may not be reliable indicators of systemic microemboli burden following CPB.