[Intestinal localization of shigellae in dysentery and experimental shigellosis]

The investigation of 53 section cases of dysentery and 18 biopsy specimens of the large intestine in acute dysentery in children showed that intrapithelial distribution of Shigella was not always regular. In studies of experimental Shigellosis on isolated loops of the intestine 459 segments of the intestine of 51 rabbits were investigated. The results obtained showed that Shigella multiplied mainly in the lumen of the intestine. The increase in number of Shigella in enterocytes was by 8-9 orders lower than that in the content of the ligated segment, whereas the number of enterocytes with Shigella was many times less than the total number of damaged cells. This confirms the conclusion that intraepithelial multiplication of Shigella is of no considerable significance in pathogenesis of dysentery.