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Centromere spreading and centromeric aberrations in ovarian tumors
1Department of Biology, Xinjiang Medical College, Urumqi, People's Republic of China.
Cancer Genetics and Cytogenetics
|March 1, 1995
Summary
Centromere spreading (CS) in ovarian tumors may be an early indicator of cancer development. This chromosomal instability can lead to aberrations, suggesting CS is a key event in tumorigenesis.
Area of Science:
- Cytogenetics
- Oncology
- Gynecologic Pathology
Background:
- Ovarian tumors, particularly papillary serous cystadenocarcinomas and borderline cystadenomas, exhibit chromosomal abnormalities.
- Centromere instability has been implicated in various cancers.
Purpose of the Study:
- To investigate the occurrence and significance of centromere spreading (CS) in ovarian epithelial tumors.
- To determine if CS is an early event in ovarian carcinogenesis.
Main Methods:
- Karyotypic analysis of chromosomes from ovarian tumor samples.
- Observation and documentation of chromosomal aberrations, specifically centromere spreading.
Main Results:
- Centromere spreading (CS) and centromeric region aberrations were observed in papillary serous cystadenocarcinomas and a borderline papillary serous cystadenoma.
- CS of chromosome 12 was noted in a borderline tumor, a chromosome previously associated with benign ovarian tumor anomalies.
Conclusions:
- Centromere spreading (CS) is suggested as an early event in the carcinogenesis of epithelial ovarian tumors.
- Chromosomal instability at centromeres may lead to premature separation and breakage, resulting in numerical and structural aberrations.