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Related Experiment Videos

Not water, but formalin, dissolves urate crystals in tophaceous tissue samples

P A Simkin1, J E Bassett, Q P Lee

  • 1Department of Medicine, University of Washington, Seattle 98195.

The Journal of Rheumatology
|December 1, 1994
PubMed
Summary

Urate crystals showed varying solubility across solvents. They were insoluble in ethanol, sparingly soluble in water, and highly soluble in formalin, suggesting chemical interactions.

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Area of Science:

  • Crystallography
  • Chemistry
  • Materials Science

Background:

  • Urate crystals are relevant in biological and chemical contexts.
  • Understanding urate crystal solubility is crucial for various applications.

Purpose of the Study:

  • To investigate the solubility of synthetic urate crystals.
  • To compare solubility in water, ethanol, and formalin.

Main Methods:

  • Synthetic urate crystals were used.
  • Incubation in water, ethanol, and formalin for 72 hours at 4°C.
  • Examination using polarized microscopy.

Main Results:

  • Urate crystals demonstrated insolubility in ethanol.
  • Sparingly soluble in water.

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  • Markedly soluble in formalin.

    • Conclusions:

    • Formalin's effectiveness in dissolving urate crystals suggests chemical reactions.
    • Formation of urate:formaldehyde addition products is indicated.