Related Experiment Videos
[Cryoglobulinemia]
1Second Department of Internal Medicine, Hyogo College of Medicine.
Cryoglobulins are proteins that precipitate when cooled and dissolve when heated. Cryoglobulinemia may be classified into Type I (monoclonal), Type II (mixed), and Type III (polyclonal). About 5 to 10% of myeloma proteins and 7 to 20% of primary macroglobulinemia proteins are cryoprecipitable (Type I cryoglobulin), and more than half of these have no symptoms attributable to cryoglobulin nature of their M-component. The most common symptoms of Type I cryoglobulinemia include Raynaud's phenomenon, necrosis of the toes or legs, vascular purpura, and urticaria. In Type I cryoglobulinemia due to plasma cell dyscrasias, treatment is directed primarily at the underlying disease. Plasmapheresis and cryofiltration may be helpful particularly when this can be combined with effective chemotherapy.
Cryoglobulins are proteins that precipitate when cooled and dissolve when heated. Cryoglobulinemia may be classified into Type I (monoclonal), Type II (mixed), and Type III (polyclonal). About 5 to 10% of myeloma proteins and 7 to 20% of primary macroglobulinemia proteins are cryoprecipitable (Type I cryoglobulin), and more than half of these have no symptoms attributable to cryoglobulin nature of their M-component. The most common symptoms of Type I cryoglobulinemia include Raynaud's phenomenon, necrosis of the toes or legs, vascular purpura, and urticaria. In Type I cryoglobulinemia due to plasma cell dyscrasias, treatment is directed primarily at the underlying disease. Plasmapheresis and cryofiltration may be helpful particularly when this can be combined with effective chemotherapy.