Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunization experiments using the rodent caries model

D J Smith, M A Taubman

    Journal of Dental Research
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Functional and immunogenic characterization of two cloned regions of Streptococcus mutans glucosyltransferase I.

    Infection and immunity·1999
    Same author

    Evaluation of linear polyethyleneimine/nitric oxide adduct on wound repair: therapy versus toxicity.

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·1999
    Same author

    In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin.

    The Journal of general virology·1999
    Same author

    It's the economy, stupid.

    Annals of plastic surgery·1998
    Same author

    Aerosolized soluble nitric oxide donor improves oxygenation and pulmonary hypertension in acute lung injury.

    American journal of respiratory and critical care medicine·1998
    Same author

    Association of salivary immunoglobulin A antibody and initial mutans streptococcal infection.

    Oral microbiology and immunology·1998

    Immunizing rats against Streptococcus mutans (S. mutans) suggests a link between salivary antibodies and reduced cavities. Further research is needed to confirm immunity

    Area of Science:

    • Oral microbiology
    • Immunology
    • Dental caries research

    Background:

    • Streptococcus mutans (S. mutans) is a primary cause of dental caries.
    • Previous immunization studies in rats suggest a correlation between salivary antibodies and reduced S. mutans-induced caries.

    Purpose of the Study:

    • To clarify the specific role of salivary antibodies in the pathogenesis of dental caries.
    • To identify necessary refinements in the rat caries model for studying immune responses.
    • To investigate the mechanisms of immunological interference with S. mutans.

    Main Methods:

    • Utilizing a rat caries model system with immunization experiments.
    • Proposing refinements such as intraductal antigen installation for local antibody response.
    • Suggesting methods to repress specific immune responses (e.g., thymectomy) and enhance monitoring techniques.

    Related Experiment Videos

  • Recommending the use of purified S. mutans antigens (GTF, cell surface) for targeted studies.
  • Considering dietary alterations and challenge dosage adjustments for sensitive in vivo detection.

    • Main Results:

    • Immunization experiments in the rat model indicate a correlation between salivary antibodies to S. mutans and reduced caries.
    • The multifactorial nature of caries prevents definitive conclusions about antibody necessity and sufficiency.
    • Current immunization methods elicit broad immune responses, complicating interpretation.

    Conclusions:

    • Evidence suggests immunological interference with S. mutans pathogenesis in the rat model.
    • Gaps in understanding the interference mechanisms and optimal study systems remain.
    • Further research is crucial to definitively establish immunity's role as an oral ecological determinant.