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Development of an improved target for [18F]F2 production
A D Roberts1, T R Oakes, R J Nickles
1Department of Medical Physics, 1530 Medical Sciences Center, Madison, WI 53706-1532.
Summary
A new A1 target significantly enhances the production of Fluorine-18 ( [18F]F2 ), a key radiotracer for medical imaging. This development offers improved yields for clinical and research applications.
Area of Science:
- Radiochemistry
- Nuclear Medicine
- Cyclotron Production
Background:
- Electrophilic [18F]F2 is a crucial radiotracer for Positron Emission Tomography (PET) imaging.
- Optimizing the production yield of [18F]F2 is essential for its widespread clinical and research use.
Purpose of the Study:
- To develop and characterize an A1 body target for improved yields of electrophilic [18F]F2.
- To assess the performance and reliability of the new target system.
Main Methods:
- Utilized a Siemens/CTI 11 MeV proton cyclotron.
- Employed an A1 body target design for [18F]F2 synthesis.
- Measured saturation yields and routine production output over extended operation.
Main Results:
- Achieved a saturation yield of 3.10 +/- 0.40 GBq/microA at beam currents up to 45 microA.
- Routinely produced 20-40 GBq of [18F]F2 for clinical and experimental use.
- Recorded a maximum yield of 45.5 GBq (1.2 Ci) after 1600 microA-h of operation.
Conclusions:
- The developed A1 body target provides significantly improved yields of electrophilic [18F]F2.
- The target demonstrates robust performance and reliability for routine radiotracer production.
- This advancement facilitates greater availability of [18F]F2 for medical applications.