Periodontal repair using PerioGlas in nonhuman primates: clinical and histologic observations

This article describes a new synthetic material for grafting periodontal osseous defects. Compared to grafts of similar-sized hydroxyapatite, tricalcium phosphate, and unimplanted controls, PerioGlas achieved histologically superior repair of surgically created defects in the monkey model. Superior repair was noted when evaluating for new bone and the degree of cementum regeneration. Epithelial downgrowth appeared to be retarded in the PerioGlas sites and not in the other materials. When comparing clinical handling characteristics, PerioGlas was found to have excellent packing and manipulative features that were preferred by the operators to the other materials. The property of epithelial downgrowth inhibition may be significant in the superior regenerative property of PerioGlas.