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[A clinico-pathological study on prognosis in node-negative breast cancer]
1Second Department of Surgery, Teikyo University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi
|March 1, 1995
Summary
Recurrence in node-negative breast cancer occurs in 10% of patients within 10 years. Tumor size, infiltration, and c-erbB-2 oncoprotein expression are key prognostic factors impacting recurrence risk.
Area of Science:
- Oncology
- Pathology
Context:
- Node-negative breast cancer presents a 10% recurrence rate within a decade post-operation.
- Historical patient cohort operated between 1960-1972 at the Cancer Institute Hospital, Tokyo.
Purpose:
- To evaluate prognostic factors influencing recurrence and survival in node-negative breast cancer.
- To identify key indicators for predicting patient outcomes.
Summary:
- Tumor diameter (>21mm) and histological infiltration diameter (>11mm) showed reduced 10-year survival rates (82.6% and 83.1% respectively).
- Factors like fatty tissue infiltration, lymphatic vessel invasion, extensive histological invasion, and numerous mitoses correlated with poor prognosis.
- Expression of c-erbB-2 oncoprotein was linked to recurrence within the first 5 years post-operation.
Impact:
- Identifies critical prognostic markers for node-negative breast cancer, aiding in risk stratification.
- Highlights the significance of c-erbB-2 oncoprotein expression in early recurrence prediction.
- Provides insights into long-term survival outcomes based on tumor characteristics.