[Immunoreactivity in the adrenal medulla in hypoxia]

Laboratory rats were exposed to influence of intermittent hypoxia every other day during the period of 11 days. Conditions similar to those of 7000 meters above sea level were imitated. Using the method of indirect immunofluorescence the state of noradrenal, adrenal and serotonin immunoreactivity of adrenal glands medulla were analyzed. After exposure of animals to influence of hypoxia adrenalin and serotonin are decreased in adrenal glands medulla, while noradrenal cells get totally emptied. The decrease of adrenal and noradrenal contents in the adrenal glands is in harmony with the knowledge about involvement of sympathoadrenal regulatory mechanisms as a response to hypoxia. The finding of decreased serotonin is explained by its simultaneous release with adrenalin from of adrenal glands medulla.