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Development of biotechnology control systems

F J Romeu1

  • 1Lead Automation Engineer, Life Sciences International, Philadelphia, PA 19103, USA.

ISA Transactions
|March 1, 1995
PubMed
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Modern biotechnology relies on advanced automation and control systems for microbial fermentation. These systems enhance yield and product quality through integrated technologies like sensors and computer-based process control.

Area of Science:

  • Biotechnology
  • Bioprocess Engineering
  • Automation and Control Systems

Background:

  • Genetic engineering advances drive interest in biotechnology.
  • Modern fermentation processes benefit from scientific optimization using instrumentation and control technology.
  • Automation significantly impacts the success of microbial cultivation.

Purpose of the Study:

  • To address technical issues in developing instrumentation and control systems for biotechnology.
  • To integrate leading automation technologies for enhanced fermentation processes.
  • To establish methodologies for timely documentation of control systems.

Main Methods:

  • Utilizing sensors, indicators, data acquisition, and distributed control systems.
  • Implementing microprocessor-based distributed process controllers for direct digital and sequence control.

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  • Leveraging modern computer systems for on-line analysis, statistical process control, and supervisory control.

    • Main Results:

    • Automation systems enhance fermentation yield and product quality.
    • Integrated technologies improve the accuracy and efficiency of microbial growth processes.
    • Computer systems and controllers facilitate complex tasks like on-line analysis and batch control.

    Conclusions:

    • Instrumentation and control systems are critical for successful modern fermentation.
    • Methodologies for control system development and documentation are essential for procurement, installation, and validation.
    • The integration of diverse automation technologies leads to optimized bioprocesses.