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Therapeutic targets in osteoarthritis
1Rheumatology Unit, University of Bristol, UK.
The Journal of Rheumatology. Supplement
|February 1, 1995
Summary
Osteoarthritis (OA) presents therapeutic targets for disease processes, including tissue repair and destruction inhibition. Novel treatments for pain and disability are also crucial for long-lived individuals.
Area of Science:
- Biomedical science
- Evolutionary biology
- Rheumatology
Background:
- Osteoarthritis (OA) is viewed as both a treatable disease and an evolutionary consequence.
- OA presents significant disadvantages for aging populations.
Purpose of the Study:
- To identify and consider therapeutic targets for osteoarthritis.
- To explore strategies for managing OA as a disease process and its evolutionary implications.
Main Methods:
- Conceptual analysis of OA as a disease and evolutionary outcome.
- Identification of potential therapeutic targets for OA management.
Main Results:
- Therapeutic targets include inhibiting tissue destruction and stimulating natural repair.
- Novel approaches for pain and physical disability management in OA are considered.
Conclusions:
- Both disease-process-oriented and evolutionary-disadvantage-oriented therapeutic strategies for OA should be pursued.
- These two approaches are not mutually exclusive and can be integrated.