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[Tenosynovitis caused by ciprofloxacin. Clinical case]
R Lara1, E Wainstein, L Guzmán
1Sección Reumatología, Facultad de Medicina (Campus Oriente), Universidad de Chile, Hospital del Salvador, Santiago de Chile.
Revista Medica De Chile
|August 1, 1994
Summary
Ciprofloxacin, an antibiotic for pyelonephritis, may cause tenosynovitis. This condition, affecting tendons, resolved after discontinuing the medication, with literature supporting this adverse drug reaction.
Area of Science:
- Pharmacology
- Infectious Diseases
- Rheumatology
Background:
- Acute pyelonephritis is a common kidney infection.
- Ciprofloxacin is a frequently prescribed fluoroquinolone antibiotic for bacterial infections.
- Diabetes mellitus is a common comorbidity in patients with infections.
Observation:
- A 67-year-old diabetic female patient was treated with ciprofloxacin for acute pyelonephritis.
- Within 12 days of treatment initiation, the patient developed tenosynovitis affecting the hand and forearm.
- Symptoms of tenosynovitis resolved after the cessation of ciprofloxacin therapy.
Findings:
- The case suggests a potential link between ciprofloxacin use and the development of tenosynovitis.
- A review of existing literature revealed other reported cases of tenosynovitis associated with ciprofloxacin.
- Tenosynovitis is identified as a possible adverse drug reaction to fluoroquinolone antibiotics.
Implications:
- Clinicians should be aware of tenosynovitis as a potential side effect of ciprofloxacin.
- Early recognition and discontinuation of the antibiotic may prevent prolonged or severe tenosynovitis.
- Further research may be warranted to elucidate the mechanism of fluoroquinolone-induced tenosynovitis.