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Oleanane and ursane glycosides from Schefflera octophylla

C Maeda1, K Ohtani, R Kasai

  • 1Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine, Japan.

Phytochemistry
|November 1, 1994
PubMed
Summary
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Researchers isolated twelve triterpene glycosides from Schefflera octophylla bark. Nine new glycosides were identified, alongside three known compounds, revealing six pairs of ursene and oleanene glycosides.

Area of Science:

  • Natural Products Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Schefflera octophylla is a plant species with potential medicinal properties.
  • Triterpene glycosides are a class of natural compounds known for diverse biological activities.

Purpose of the Study:

  • To isolate and elucidate the structures of triterpene glycosides from the bark of Schefflera octophylla of Vietnamese origin.
  • To characterize new glycosides and compare them with known compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation through comprehensive chemical and spectroscopic analyses (e.g., NMR, Mass Spectrometry).

Main Results:

  • Twelve triterpene glycosides were isolated, including three known compounds: asiaticoside, cauloside D, and a specific 3 alpha-hydroxyurs-12-ene-23,28-dioic acid derivative.

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  • Nine novel glycosides were identified and their structures elucidated.
  • The 12 glycosides comprised six pairs of related ursene and oleanene glycosides, all sharing a common triose moiety at the C-28 position.
  • Proposed names for the new compounds: scheffurosides A-F and scheffoleosides B-F.
  • Conclusions:

    • The study successfully identified and characterized a series of triterpene glycosides from Schefflera octophylla.
    • The findings expand the knowledge of the chemical diversity of triterpene glycosides in this plant species.
    • The structural similarity among the isolated glycosides suggests a common biosynthetic pathway.