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Amino acid sequence of natural tumor necrosis factor alpha inhibitor purified from human urine
J Kajihara1, A Asada, S Kirihara
1Biochemistry Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan.
Bioscience, Biotechnology, and Biochemistry
|December 1, 1994
Abstract:
Tumor necrosis factor alpha inhibitor (TNF-INH) was purified from human urine and it was composed of 161 amino acid residues. The complete amino acid sequence of TNF-INH found by sequence analysis agreed with that predicted from the cDNA structure for the extracellular domain (1-161 portion) of 55-kDa TNF receptor and its processing site at the C-terminal was Asn-161.