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Basic fibroblast growth factor in human saliva: detection and physiological implications

G B van Setten1

  • 1Karolinska Institutet, Stockholm, Sweden.

The Laryngoscope
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

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Basic fibroblast growth factor (bFGF) was detected in human saliva samples. This finding suggests bFGF may be a constant component of saliva, with implications for its physiological role.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Human Physiology

Background:

  • Epidermal growth factor and transforming growth factor alpha are found in human body fluids, including saliva.
  • Basic fibroblast growth factor (bFGF) is known to stimulate cell proliferation and angiogenesis.

Purpose of the Study:

  • To investigate the presence and concentration of basic fibroblast growth factor (bFGF) in human saliva.
  • To determine if bFGF is a constant component of human saliva.

Main Methods:

  • Establishment of an Enzyme-Linked Immunosorbent Assay (ELISA) technique for bFGF detection.
  • Collection of saliva samples from eight healthy individuals.
  • Analysis of 16 saliva samples (run in duplicate) for bFGF content.

Related Experiment Videos

Main Results:

  • Measurable amounts of bFGF were found in 14 out of 16 (87.5%) investigated saliva samples.
  • bFGF concentrations ranged from 0.1 pg/mL to 8.4 pg/mL, with a mean of 3.8 pg/mL.
  • No significant correlation was observed between bFGF concentrations and the age or sex of individuals.

Conclusions:

  • Basic fibroblast growth factor (bFGF) is present in human saliva.
  • bFGF may be a constant component of human saliva.
  • The physiological significance of bFGF in saliva warrants further investigation.