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Updated: Aug 5, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

[Cholera in Makhachkala during the 1994 epidemic]

S M Mamaeva, E A Moskvitina, G G Onishchenko

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |March 1, 1995
    PubMed

    Insights

    Imported cholera cases were significant in Makhachkala, with day contacts being the primary transmission route. Control measures successfully prevented widespread outbreaks by targeting transmission pathways.

    Area of Science:

    • Epidemiology
    • Infectious Diseases
    • Public Health

    Context:

    • Cholera outbreak investigation in Makhachkala during an epidemic period.
    • Detection of 51 cholera patients and 27 Vibrio carriers.
    • Significant proportion of cases (30.7%) linked to imported infections amid population migration.

    Purpose:

    • To analyze the transmission routes and characteristics of a cholera epidemic in Makhachkala.
    • To evaluate the effectiveness of implemented cholera control measures.
    • To understand the dynamics of the epidemic process in a specific urban setting.

    Summary:

    • The study identified day contacts (43.3%) as the leading transmission route, followed by alimentary (28.4%) and water (14.9%) routes.
    • The epidemic presented as a mild, prolonged process, with imported cases playing a notable role.
    • A comprehensive set of control measures, focusing on disrupting transmission routes, was effective in preventing mass diseases.

    Impact:

    • Highlights the importance of targeted interventions to control cholera spread, especially in high-migration areas.
    • Provides insights into the epidemiology of cholera transmission in urban environments.
    • Demonstrates the success of public health strategies in mitigating epidemic impact.

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